Trauma Research Newsletter!

As we begin to work on our summer reading lists, we have another offering to add: the new Trauma Research newsletter is now available!

From the news: High heels and traumatic injury

Just in time for the controversy over Jurassic Park’s leading female star fighting dinosaurs in heels, a recent study out of the University of Alabama at Birmingham found high-heeled-shoe-related injuries have nearly doubled between 2002 and 2012. In 2011 alone, there were over 19,000 reports of injury due to heels. More than three quarters of the injuries were to the ankle or foot, and the most common diagnosis was a sprain or strain. Is the risk of an ankle sprain convincing enough to toss your heels? Probably not.

Abstract accepted to the American Neurological Association!

Congratulations to Jan Leonard and the Stroke Team at Swedish Medical Center for getting their abstract, entitled “Estimated Weight to Dose tPA can Harm Elderly Ischemic Stroke Patients,” accepted to the American Neurological Association. The conference is to be held in Chicago, IL September 27 – 29!

New publication on low molecular weight fraction of commercial 5% human serum albumin

Dr. David Bar-Or and his team have published a new article on the anti-inflammatory properties of low molecular weight fraction of commercial 5% human serum albumin (LMWF5A), and its potential impacts on osteoarthritis.

In the study, entitled “Low Molecular Weight Fraction of Commercial Human Serum Albumin Induces Morphologic and Transcriptional Changes of Bone Marrow-Derived Mesenchymal Stem Cells,” bone marrow-derived mesenchymal stem cells exposed toLMWF5A exhibited an elongated phenotype with diffuse intracellular F-actin, pronounced migratory leading edges, and filopodia-like projections. In addition, LMWF5A promoted chondrogenic condensation in “micromass” culture, concurrent with the upregulation of collagen 2a1 mRNA.

The study concludes that LMWF5A can alter stem cells function and that the proteomic changes in the synovial fluid of patients receiving treatment indicate that these observations translate, in part, in vivo. Consequently, LMWF5A could prove to be a viable alternative to the existing strategies for the treatment of OA of the knee or possibly enhance the efficacy of existing protocols by locally affecting extracellular matrix deposition, enhancing mesenchymal stem cell differentiation and/or mobilizing.

Read more about the article here.

Two abstracts accepted to the Rocky Mountain Neurosurgical Society

Kristin Salottolo and colleagues will be presenting two exciting abstracts at the Rocky Mountain Neurosurgical Society‘s 50th Annual meeting, held June 20-24th in Colorado Springs, CO!

Abstract titles:

Epidemiology Of Traumatic Brain Injury With Glasgow Coma Scale 3: A Multicenter Study. 

Aggressive Operative Neurosurgical Management is Associated with Survival Benefit in Severe Traumatic Brain Injury and Glasgow Coma Scale of 3: A Propensity Matched Analysis.

A new manuscript discussing treatments in osteoarthritis

Osteoarthritis is a leading cause of disability in the United States. In Dr. Bar-Or and team’s most recent article, new therapies focusing on promoting the transition from pro-inflammatory to anti-inflammatory prostaglandins for osteoarthritis are discussed. Read more here!

Viva la AAST!

We are proud to have three AAST abstracts accepted for presentation at the upcoming annual meeting for the Annual Association for the Surgery of Trauma September 9 – 12, in Las Vegas:

TYPE 1 DIABETES INCREASES ODDS OF VENOUS THROMBOEMBOLISM FOLLOWING TRAUMATIC INJURY

PROGNOSIS OF PATIENTS WITH SEVERE TRAUMATIC BRAIN INJURY WITH GLASGOW COMA SCALE OF 3 IS PREDICTED BY SIMPLE CRITERIA KNOWN ON ED ARRIVAL

THE RISK OF NEUROSURGERY AND MORTALITY IN A POPULATION WITH MILD TRAUMATIC BRAIN INJURY AND INTRACRANIAL HEMORRHAGE: A THREE-YEAR MULTI-CENTER RETROSPECTIVE OBSERVATIONAL STUDY

As always, please review our upcoming presentations to see our next stops!

New publication on low molecular weight fraction of commercial human serum albumin and osteoarthritis

Congratulations to David Bar-Or and the trauma research team and partners for producing a new publication analyzing the anti-inflammatory properties of the low molecular weight fraction of commercial human serum albumin (LMWF5A) in relation to osteoarthritis of the knee, published in the Journal of Immunoassay and Immunochemistry. Read the article here!

This Newsletter is a #throwback!

2012 was a momentum year – President Obama won a second term in office, Encyclopædia Britannica  ended it’s 244 years of publication, the Facebook IPO flopped, and Austrian skydiver Felix Baumgartner becomes the first person to break the sound barrier. Oh, and Trauma Research had some pretty interesting publications! Check out the latest newsletter here – it’s a #throwback!

A spring of publications!

Faster than you can say Jack Robinson, we published four studies, currently available online.

Enjoy!:

Stagos D, Goutzourelas N, Ntontou AM, Kafantaris I, Deli CK, Poulios A, Jamurtas AZ, Bar-Or D,Kouretas D. Assessment of eccentric exercise-induced oxidative stress using oxidation-reduction potential markers. Oxid Med Cell Longev. 2015. [Epub ahead of print].

Hausburg MA, Doles JD, Clement SL, Cadwallader AB, Hall MN, Blackshear PJ, Lykke-Andersen J, Olwin BB. Post-transcriptional regulation of satellite cell quiescence by TTP-mediated mRNA decay. 2015.Elife: Mar 27;4 [Epub ahead of print].

Bar-Or D, Carrick MM, Mains CW, Rael LT, Slone D, Brody EN. Sepsis, oxidative stress, and hypoxia: Are there clues to better treatment? Redox Rep. 2015 Mar 24:RER11325. [Epub ahead of print]

Milic S, Pristov JB, Mutavdzic D, Savic A, Spasic M, Spasojevic. The relationship of physiochemical properties to the antioxidative activity of free amino acids in Fenton system. Environ Sci Technol.2015 March 12 [Epub ahead of print]

As always, please click here for a complete list of publications.