New publication: Oxidative Stress in Septic and Obese Patients

We are proud to have published an additional study examining oxidative stress measured via oxidation reduction potential (ORP), specifically static (sORP) and capacity (cORP) oxidation-reduction potential markers as well as conventional oxidative stress biomarkers of total antioxidant capacity (TAC), thiobarbituric acid-reactive substances (TBARS) and protein carbonyls (CARB), in plasma of patients with sepsis. Further, the effect of obesity-induced oxidative stress on patients with sepsis was also studied. It was found the sORP marker was significantly higher in the sepsis group, while cORP was significantly lower compared to the control group, indicating oxidative stress.Furthermore, in patients with sepsis, TAC was significantly lower compared to control group. However, obesity had no effect on sORP, cORP and TAC in patients with sepsis, although it increased levels of CARB and TBARS. The present results suggest, for the first time, that ORP markers could be used for assessing oxidative stress in patients with sepsis. We recommend reviewing the full article in In Vivo!

Trauma Research presentation schedule: 2015 AAST

Trauma Research is proud to be presenting the following presentations next week at the 74^th Annual Meeting of AAST and Clinical Congress of Acute Care Surgery located at the Wynn, Las Vegas, NV:

Wednesday, September 9; 1:20-1:40 in the Latour Ballroom

INTRAOPERATIVE HYPOTENSIVE RESUSCITATION FOR PATIENTS UNDERGOING LAPAROTOMY OR THORACOTOMY FOR TRAUMA: EARLY TERMINATION OF A RANDOMIZED PROSPECTIVE CLINICAL TRIAL, Presented by Dr. Matthew Carrick

Wednesday, September 9; 5:30-7:30 in the LaFite Ballrooms

TYPE 1 DIABETES INCREASES ODDS OF VENOUS THROMBOEMBOLISM FOLLOWING TRAUMATIC INJURY, Presented by Jan Leonard

PROGNOSIS OF PATIENTS WITH SEVERE TRAUMATIC BRAIN INJURY WITH GLASGOW COMA SCALE OF 3 IS PREDICTED BY SIMPLE CRITERIA KNOWN ON ED ARRIVAL, Presented by Kristin Salottolo

THE RISK OF NEUROSURGERY AND MORTALITY IN A POPULATION WITH MILD TRAUMATIC BRAIN INJURY AND INTRACRANIAL HEMORRHAGE: A THREE-YEAR MULTI-CENTER RETROSPECTIVE OBSERVATIONAL STUDY, Presented by Alessandro Orlando

Safe boating is no accident, and there’s a study to prove it.

During these dog days of summer, it seems everyone is trying to find just one day to spend on the lake. A recent study in the journal Risk Analysis found increasing the use of life jackets by just 20% would have saved the lives of 1721 American boaters, out of the 3047 boat-involved fatalities within a four year period. Using data from the U.S. Coast guard, the study found the presence of a life jacket increased the odds of surviving a boating accident by 80%. It is hopeful that such a finding can spur evidence-based policy change in the near future. Read the full version here.

Assessing oxidation reduction potential

Congratulations to Leonard Rael and team for recently publishing a manuscript describing the technical components of the electrode that measures oxidation reduction potential. Read more in Electroanalysis.

Intra-Arterial Therapy is Safe and Effective in Patients Aged >80

We are excited to announce a new publication on intra-arterial therapy in patients ≥80 years old, in the most recent issue of Cerebrovascular Diseases.

Recently, clinical trials confirmed the safety and efficacy of performing intra-arterial therapy to manage patients with ischemic stroke. In our recent study, we compared outcomes in patients aged ≥80 to patients in the age range 55-79 years who were treated with intra-arterial therapy after ischemic stroke at a community hospital.

No differences were found in mortality, symptomatic hemorrhage rate, or functional outcomes between the two age groups, suggesting age ≥80 should not be a contraindication to IAT.

Read more in Cerebrovascular Diseases.

Trauma Research Newsletter!

As we begin to work on our summer reading lists, we have another offering to add: the new Trauma Research newsletter is now available!

From the news: High heels and traumatic injury

Just in time for the controversy over Jurassic Park’s leading female star fighting dinosaurs in heels, a recent study out of the University of Alabama at Birmingham found high-heeled-shoe-related injuries have nearly doubled between 2002 and 2012. In 2011 alone, there were over 19,000 reports of injury due to heels. More than three quarters of the injuries were to the ankle or foot, and the most common diagnosis was a sprain or strain. Is the risk of an ankle sprain convincing enough to toss your heels? Probably not.

Abstract accepted to the American Neurological Association!

Congratulations to Jan Leonard and the Stroke Team at Swedish Medical Center for getting their abstract, entitled “Estimated Weight to Dose tPA can Harm Elderly Ischemic Stroke Patients,” accepted to the American Neurological Association. The conference is to be held in Chicago, IL September 27 – 29!

New publication on low molecular weight fraction of commercial 5% human serum albumin

Dr. David Bar-Or and his team have published a new article on the anti-inflammatory properties of low molecular weight fraction of commercial 5% human serum albumin (LMWF5A), and its potential impacts on osteoarthritis.

In the study, entitled “Low Molecular Weight Fraction of Commercial Human Serum Albumin Induces Morphologic and Transcriptional Changes of Bone Marrow-Derived Mesenchymal Stem Cells,” bone marrow-derived mesenchymal stem cells exposed toLMWF5A exhibited an elongated phenotype with diffuse intracellular F-actin, pronounced migratory leading edges, and filopodia-like projections. In addition, LMWF5A promoted chondrogenic condensation in “micromass” culture, concurrent with the upregulation of collagen 2a1 mRNA.

The study concludes that LMWF5A can alter stem cells function and that the proteomic changes in the synovial fluid of patients receiving treatment indicate that these observations translate, in part, in vivo. Consequently, LMWF5A could prove to be a viable alternative to the existing strategies for the treatment of OA of the knee or possibly enhance the efficacy of existing protocols by locally affecting extracellular matrix deposition, enhancing mesenchymal stem cell differentiation and/or mobilizing.

Read more about the article here.

Two abstracts accepted to the Rocky Mountain Neurosurgical Society

Kristin Salottolo and colleagues will be presenting two exciting abstracts at the Rocky Mountain Neurosurgical Society‘s 50th Annual meeting, held June 20-24th in Colorado Springs, CO!

Abstract titles:

Epidemiology Of Traumatic Brain Injury With Glasgow Coma Scale 3: A Multicenter Study. 

Aggressive Operative Neurosurgical Management is Associated with Survival Benefit in Severe Traumatic Brain Injury and Glasgow Coma Scale of 3: A Propensity Matched Analysis.